1-Minute Summary: Development and Preliminary Validation of a New Patient-Reported Outcome Measure for Chronic Rhinosinusitis (CRS-PRO)

Expert Name
Dr Saied Ghadersohi

Ghadersohi S, Price CPE, Jensen SE, et al. Development and Preliminary Validation of a New Patient-Reported Outcome Measure for Chronic Rhinosinusitis (CRS-PRO). J Allergy Clin Immunol Pract. 2020;8(7):2341-2350.e1. Chronic rhinosinusitis (CRS) is an inflammatory disease of the nasal airways and paranasal sinuses with a high disease burden [1,2]. Patient-reported outcome (PRO) instruments are measures of disease severity and symptom burden in…

1-Minute Summary: Altered Mitochondrial Functions and Morphologies in Epithelial Cells Are Associated With Pathogenesis of Chronic Rhinosinusitis With Nasal Polyps

Expert Name
Dr Young Hoon Yoon

Young HY, Sun HE, et al. Altered Mitochondrial Functions and Morphologies in Epithelial Cells Are Associated With Pathogenesis of Chronic Rhinosinusitis With Nasal Polyps. Allergy Asthma Immunol Res. 2020 Jul;12(4):653-668 Chronic rhinosinusitis with nasal polyps (CRSwNP) is a complex inflammatory disease of the nasal and paranasal sinus mucosa [1]. There are indications that the disease is associated with mitochondrial dysfunction,…

1-Minute Summary: A Network Meta-Analysis of Randomised Controlled Trials on the Treatment of Eosinophilic Esophagitis in Adults and Children

Expert Name
Dr Theodore Rokkas

Rokkas T, et al. A network meta-analysis of randomized controlled trials on the treatment of eosinophilic esophagitis in adults and children. J Clin Gastroenterol 2020; published ahead of print. For eosinophilic esophagitis (EoE), apart from steroids [1], newer therapeutic interventions and relevant randomised controlled trials (RCTs) are available that have not been included in previous meta-analyses [2-6]. Network meta-analysis (NWM)…

1-Minute Summary: Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and receptors in type 1, type 2 and type 17 inflammation in cross-sectional asthma study

Expert Name
Dr Michelle Marks

Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and receptors in type 1, type 2 and type 17 inflammation in cross-sectional asthma study. Thorax 2020;0:1–4. Epub Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) has a potential role in allergic asthma [1,2]. TRAIL induces apoptosis in a variety of cells thereby resolving inflammation [1,3]. Conversely, TRAIL has been shown to promote eosinophil survival in…

1-Minute Summary: Management of severe asthma: a European Respiratory Society/American Thoracic Society guideline

Expert Name
Prof. Fernando Holguin

In 2014, the first guidelines for the treatment of severe asthma in children and adults were composed by the European Respiratory Society/American Thoracic Society (ERS/ATS) [1]. Since 2017, a multidisciplinary Task Force of asthma experts, co-chaired by Dr Fernando Holguin and Dr Andy Bush, has worked on an updated version. The Task Force made 6 recommendations that were not addressed…

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1-Minute Summary: EUFOREA Consensus on Biologics for CRSwNP with or without Asthma

Expert Name
Dr. Wytske Fokkens

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory condition of the sinonasal cavities [1-3]. It is frequently comorbid with asthma and both diseases share common underlying pathophysiological mechanisms driving the disease, including type 2 inflammation [3-9]. CRSwNP severely impacts quality of life and has a significant burden on society [10-12]. When symptoms are persistent or when there is…

1-Minute Summary: Biomarkers in asthma management: Time to move forward

Expert Name
Prof. Kjell Alving

Alving K, Diamant Z, Lucas S, et al. Point‐of‐care biomarkers in asthma management: Time to move forward Allergy. Allergy. 2020;75(4):995‐997. The Global Initiative for Asthma (GINA) report has directed clinical guidelines for asthma since 2014. Evidence comes from randomised controlled trials, but not from real-world or observational studies, which could be a limitation [1]. Asthma is a heterogeneous condition with…