Locally active corticosteroid promising in eosinophilic oesophagitis

Orodispersible budesonide delivered specifically to the oesophagus as a tablet was effective in inducing clinical and histological remission in patients with eosinophilic oesophagitis, according to the data from the EOS-2 trial, reported by Prof. Alfredo Lucendo (Tomelloso General Hospital, Spain) [1]. EOS-2 aimed to test the efficacy of a 6-week open-label induction treatment with oral budesonide (1 mg, twice daily)…

Small molecules: interesting novel treatment options in AD

There is a high need for oral treatments for atopic dermatitis (AD) that cannot be controlled with local therapy. Both phosphodiesterase (PDE) inhibitors and Janus kinase (JAK) inhibitors are interesting approaches [1]. PDE4 is involved in the regulation of pro-inflammatory cytokines via the degradation of cyclic adenosine monophosphate. Targeting PDE4 reduces the production of pro-inflammatory mediators in AD and may…