1-Minute Summary: Diagnostic and Therapeutic Value of Hsa_circ_0002594 for T Helper 2-Mediated Allergic Asthma

Expert Name
Dr Z. Huang

Asthma is a heterogeneous, chronic lung disease driven by both genetic and environmental factors [1,2]. The current study investigated the involvement of circular RNA (circRNA) in asthma, in particular allergic asthma mediated by CD4+ T cells, and its potential diagnostic and therapeutic value [1,3,4]. Patients with asthma (n=83) and healthy controls (n=54) were included [1]. The circRNA hsa_circ_0002594 previously identified…

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1-Minute Summary: COVID-19 in severe asthmatic patients during ongoing treatment with biologicals targeting type 2 inflammation: Results from a multicenter Italian survey

Expert Name
Andrea Matucci, MD

In this descriptive study the association between severe asthma, biological therapy, and SARS-CoV-2 infection was investigated [1]. A higher risk for viral infections was described previously for asthmatic patients [2,3]. Because SARS-CoV-2 has demonstrated a predisposition to infect the upper and the lower respiratory tract, it may create a higher clinical issue for this patient group [4]. However, it should…

1-Minute Summary: Role of IL-25, IL-33, and TSLP in triggering united airway diseases toward type 2 inflammation

Expert Name
Haiyu Hong

The concept of united airway diseases (UAD) includes allergic rhinitis (AR), chronic rhinosinusitis (CRS), and asthma, all of which share common immune-pathogenic mechanisms [1-4]. Moreover, a systemic link between upper and lower airways exists by shared molecular and inflammatory mechanisms, including overproduction of type-2 cytokines in AR, CRS, and asthma [5,6], not limited to the target organs. There is a…

1-Minute Summary: Dupilumab Improves Clinical Outcomes in Patients with Asthma and Perennial Allergic Rhinitis

Expert Name
Dr William W. Busse

Efficacy of dupilumab on clinical outcomes in patients with asthma and perennial allergic rhinitis [published online ahead of print, 2020 May 28]. Ann Allergy Asthma Immunol. 2020;S1081-1206(20)30389-6. In this post-hoc analysis of the phase 3 LIBERTY ASTHMA QUEST trial, the effect of dupilumab on comorbid perennial allergic rhinitis (PAR) was investigated. PAR is often associated with sensitisation to indoor allergens…

1-Minute Summary: Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and receptors in type 1, type 2 and type 17 inflammation in cross-sectional asthma study

Expert Name
Dr Michelle Marks

Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and receptors in type 1, type 2 and type 17 inflammation in cross-sectional asthma study. Thorax 2020;0:1–4. Epub Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) has a potential role in allergic asthma [1,2]. TRAIL induces apoptosis in a variety of cells thereby resolving inflammation [1,3]. Conversely, TRAIL has been shown to promote eosinophil survival in…

Clinical assessment and management of different endotypes and phenotypes of severe asthma

Expert Name
Dr Liam Heaney

Dr Liam Heaney is a professor of respiratory medicine at Queen’s University Belfast (UK) and a consultant physician at Belfast City Hospital. He leads the Medical Research Council Refractory Stratification Programme (RASP-UK) to transform clinical management of severe asthma, produce more personalised treatment approaches and investigate novel treatment strategies. Prof. Heaney also founded the British Thoracic Society Difficult Asthma Network…

1-Minute Summary: Management of severe asthma: a European Respiratory Society/American Thoracic Society guideline

Expert Name
Prof. Fernando Holguin

In 2014, the first guidelines for the treatment of severe asthma in children and adults were composed by the European Respiratory Society/American Thoracic Society (ERS/ATS) [1]. Since 2017, a multidisciplinary Task Force of asthma experts, co-chaired by Dr Fernando Holguin and Dr Andy Bush, has worked on an updated version. The Task Force made 6 recommendations that were not addressed…

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1-Minute Summary: EUFOREA Consensus on Biologics for CRSwNP with or without Asthma

Expert Name
Dr. Wytske Fokkens

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory condition of the sinonasal cavities [1-3]. It is frequently comorbid with asthma and both diseases share common underlying pathophysiological mechanisms driving the disease, including type 2 inflammation [3-9]. CRSwNP severely impacts quality of life and has a significant burden on society [10-12]. When symptoms are persistent or when there is…

1-Minute Summary: Biomarkers in asthma management: Time to move forward

Expert Name
Prof. Kjell Alving

Alving K, Diamant Z, Lucas S, et al. Point‐of‐care biomarkers in asthma management: Time to move forward Allergy. Allergy. 2020;75(4):995‐997. The Global Initiative for Asthma (GINA) report has directed clinical guidelines for asthma since 2014. Evidence comes from randomised controlled trials, but not from real-world or observational studies, which could be a limitation [1]. Asthma is a heterogeneous condition with…

Holistic View on Asthma

Expert Name
Prof. Zuzana Diamant

In the past 15 years, striking progress has been made in our understanding of the mechanisms underlying chronic inflammatory airway disease as well as the predisposing and interfering factors. These insights have resulted in a more holistic and personalised approach to the diagnosis and management of chronic inflammatory airway diseases including their comorbidities. At the annual congress of the European…