“As-needed” inhaled corticosteroid therapy for mild asthma – what is the evidence?

Expert Name
Prof. Kaharu Sumino
Expert Affiliation
Washington University School of Medicine, MO, USA
Conference
ATS 2021

Several recent studies assessed the benefit of as-needed inhaled corticosteroid (ICS) treatment for mild asthma. An advantage of this approach is the ICS sparing effect, which was evident both in randomised clinical trials and practice studies.

The traditional management of persistent asthma consists of a controller medication daily and reliever medication as needed. “This procedure was the guideline´s first choice over 3 decades,” Prof. Kaharu Sumino (Washington University School of Medicine, MO, USA) said in her introduction [1]. However, delivery of daily ICS therapy has been challenging, especially due to adherence of <50%. Obviously, enforcing daily ICS when symptoms are not severe is difficult. “Mild asthma can be associated with significant morbidity and mortality,” Prof. Sumino said. A total of 16% of near-fatal asthma and 15% of adults dying from asthma had less than weekly symptoms 3 months before the event [2]. This is the rationale to use non-regular ICS therapies in treating mild asthma, which affects the majority of patients (50–70%) [2]. Potential benefits of as-needed ICS application include a higher sense of self-management by patients. Currently, more evidence is available on as-needed ICS in mild asthma. This reflects in landmark changes in the Global Initiative for Asthma (GINA) guideline in 2019 and the National Asthma Education Prevention Program (NAEPP) guideline in 2020.

Prof. Anne Dixon (University of Vermont, MA, USA) discussed as-needed ICS therapy in adults with mild asthma. In both the GINA and NAEPP guidelines, mild asthma is defined as asthma controlled on step 1 or step 2 treatment, but there are slight differences (see Table) [3]. “What they have in common is the use of as-needed ICS,” Prof. Dixon said. As-needed ICS is what patients do already – they use an inhaler when they have symptoms. Another advantage of providing ICS at the time of symptoms is that anti-inflammatory therapy is given when it is most needed.

Table: Mild asthma treatment options in the NAEPP 2020 update versus GINA 2020 [1]

GINA, Global Initiative for Asthma; NAEPP, National Asthma Education Prevention Program; SABA, Short-acting β-agonists; ICS, inhaled corticosteroids.

Only data for the combination budesonide-formoterol

As-needed ICS-formoterol for mild asthma was only studied as budesonide-formoterol combination, a combination that was not yet addressed in the NAEPP update. In the SYGMA 1 trial (NCT02149199) including 3,849 patients with mild asthma that needed step 2 treatment, as-needed budesonide-formoterol provided superior asthma-symptom control to as-needed terbutaline, assessed using electronically recorded weeks with well-controlled asthma for a period of 52 weeks [4]. “Budesonide maintenance was slightly better,” Prof. Dixon said. In the SYGMA 2 trial (NCT02224157), a similar patient population was included (n=4,215) [5]. In this 52-week, non-inferiority trial, budesonide–formoterol used as needed was non-inferior to twice-daily budesonide concerning the rate of severe asthma exacerbations but was inferior in controlling asthma symptoms. Another advantage of the as-needed approach was the median daily dose of ICS being 75% lower in the budesonide–formoterol group. These results are backed by 2 studies reflecting a real-life scenario. In the 52-week, real-world, open-label superiority study PRACTICAL (U1111-1174-2273), 890 patients were included and treated with budesonide–formoterol reliever therapy compared with maintenance budesonide plus as-needed terbutaline. Severe exacerbations per patient per year were lower with as-needed budesonide–formoterol than with maintenance budesonide plus terbutaline as needed. In addition, asthma control did not differ between treatment groups. Again, patients treated with as-needed ICS-formoterol had an ~50% lower ICS dose versus budesonide maintenance [5].

The START trial (2015-002384-42) had a similar result: in this 52-week, real-world, open-label study, 668 asthma patients were either treated with albuterol, budesonide plus as-needed albuterol (budesonide maintenance group) or budesonide-formoterol [6,7]. The annualised exacerbation rate in the budesonide–formoterol group was lower than that in the albuterol group (P<0.001) and did not differ significantly from the rate in the budesonide maintenance group (P=0.65). In both trials, ICS–formoterol-treated patients needed an ~50% reduced ICS dose.

“In conclusion, we have less data regarding as-needed ICS-formoterol for step 1, but very compelling data for step 2,” Prof. Dixon said. As-needed ICS-formoterol reduces the risk of exacerbations compared with as-needed short-acting beta-agonists. In real-world studies, it also reduced severe exacerbations and had a similar effect on symptom scores compared with regularly scheduled ICS, with a lower ICS dose.

  1. Sumino KC. Introduction of symposium: as-needed ICS therapy in mild asthma, case presentation and guidelines. Session C006: Are we ready for “as-needed” inhaled corticosteroid therapy for mild asthma? Different patients, different perspectives. ATS 2021 International Conference, 14-19 May.
  2. Dusser D, et al. Allergy 2007;62(6):591-604.
  3. Dixon A. Adult perspectives of as-needed ICS therapy in mild asthma. Session C006: Are we ready for “as-needed” inhaled corticosteroid therapy for mild asthma? Different patients, different perspectives. ATS 2021 International Conference, 14-19 May.
  4. O’Byrne PM, et al. N Engl J Med 2018:378(20):1865-76.
  5. Bateman ED, et al. New Engl J Med 2018;378:1877-87.
  6. Hardy J, et al. The Lancet 2019;394:919-28.
  7. Beasley R, et al. New Engl J Med 2019;380:2020-30.

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